Matrix-Induced Autologous Chondrocyte Implantation

Matrix-induced autologous chondrocyte implantation is a third-generation autologous chondrocyte implantation technique that can be used for treating chondral and osteochondral lesions. Harvested chondrocytes are expanded in number and seeded onto a type I/III collagen membrane. The matrix-induced autologous chondrocyte implantation graft is secured within the debrided defect with fibrin sealant, which produces a stable reconstruction. Most clinical experience relates to its use in the knee joint, where a number of series report good clinical outcome up to 5 years postsurgery.

Keywords: matrix-induced autologous chondrocyte implantation (MACI), chondrocyte, osteochondral defect, surgical technique, outcome