Operative Techniques in Orthopaedics
Volume 16, Issue 4 , Pages 218-226 , October 2006

Articular Cartilage Repair: Clinical Approach and Decision Making

  • Riley J. Williams, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Riley J. Williams, MD, Institute for Cartilage Repair, Hospital for Special Surgery, 535 E. 70th Street, New York, NY 10021.

References 

  1. Curl W, Krome J, Gordon E, et al. Cartilage injuries: a review of 31,516 knee arthroscopies. Arthroscopy. 1997;13:456–460
  2. Hjelle K, Solheim E, Strand T, et al. Articular cartilage defects in 1,000 knee arthroscopies. Arthroscopy. 2002;18:730–734
  3. Hunziker E. Articular cartilage repair: basic science and clinical progress (A review of the current status and prospects). Osteoarthritis Cartilage. 2001;10:432–463
  4. Martinek V, Ueblacker P, Imhoff A. Current concepts of gene therapy and cartilage repair. J Bone Joint Surg [Br]. 2003;85B:782–788
  5. Vangsness C, Kurzweil P, Lieberman J. Restoring articular cartilage in the knee. Am J Orthopedics. 2004;33(suppl):29–34
  6. Hunter W. On the structure and diseases of articulating cartilages. Philos Trans R Soc Lond. 1743;42B:514–521
  7. Mankin H. The response of articular cartilage to mechanical injury. J Bone Joint Surg. 1982;64A:460–466
  8. Newman A. Articular cartilage repair. Am J Sports Med. 1998;26:309–324
  9. Buckwalter J. Articular cartilage injuries. Clin Orthop. 2002;402:21–37
  10. Buckwalter J, Mankin H. Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect. 1998;47:487–504
  11. Buckwalter J, Mankin H. Articular cartilage: tissue design and chondrocyte-matrix interactions. Instr Course Lect. 1998;47:477–486
  12. Caplan A, Elyaderani M, Mochizuki Y, et al. Principles of cartilage repair and regeneration. Clin Orthop. 1997;342:254–269
  13. Lefkoe T, Trafton P, Ehrlich M, et al. An experimental model of femoral condylar defect leading to osteoarthosis. J Orthop Trauma. 1993;7:458–467
  14. Brittberg M, Lindhal A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation of the knee. N Engl J Med. 1994;331:889–895
  15. Peterson L, Minas T, Brittberg M, et al. Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop. 2000;374:212–234
  16. Hangody L, Kish G, Karpati Z, et al. Mosaicplasty for the treatment of articular cartilage defects: Application in clinical practice. Orthopedics. 1998;21:751–756
  17. Johnson L. Clinical methods of cartilage repair. Arthroscopic abrasion arthroplasty. A review. Clin Orthop. 2001;391S:306–317
  18. Rodrigo J, Steadman J, Silliman J. Improvement of full-thickness chondral defect healing in the human knee after debridement and microfracture using continuous passive motion. Am J Knee Surg. 1994;7:109–116
  19. Rae P, Noble J. Arthroscopic drilling of osteochondral lesions of the knee. J Bone Joint Surg [Br]. 1989;71B:534
  20. Bert J. Role of abrasion arthroplasty and debridement in the management of osteoarthritis of the knee. Rheum Dis Clin North Am. 1993;19:725–739
  21. Steadman J, Rodkey W, Rodrigo J. Microfracture: surgical technique and rehabilitation to treat chondral defects. Clin Orthop. 2001;391(suppl):
  22. Mithoefer K, Williams R, Warren R, et al. The microfracture technique for the treatment of articular cartilage lesions in the knee (A prospective cohort study). J Bone Joint Surg. 2005;87A:1911–1920
  23. Meyers M, Akeson W, Convery F. Resurfacing of the knee with fresh osteochondral allograft. J Bone Joint Surg. 1989;71A:704–713
  24. Minas T, Chiu R. Autologous chondrocyte implantation. Am J Knee Surg. 2000;13:41–50
  25. Bugbee W, Convery F. Osteochondral allograft transplantation. Clin Sports Med. 1999;18:67–75
  26. Brittberg M, Tallheden T, Sjogren-Jansson B, et al. Autologous chondrocytes used for articular cartilage repair: an update. Clin Orthop. 2001;391(suppl):S337–S348
  27. Potter H, Linklater J, Allen A, et al. Magnetic resonance imaging of articular cartilage in the knee (An evaluation with use of fast-spin-echo imaging). J Bone Joint Surg. 1998;80A:1276–1284
  28. Felson D, Goggins J, Niu J, et al. The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum. 2004;50:3904–3909
  29. Tetsworth K, Paley D. Malalignment and degenerative arthropathy. Orthop Clin North Am. 1994;25:367–377
  30. Goodman S, Lee J, Smith R, et al. Mechanical overload of a single compartment induces early degenerative changes in the rabbit knee: a preliminary study. J Invest Surg. 1991;4:161–170
  31. Outerbridge R. The etiology of chondromalacia patellae. J Bone Joint Surg [Br]. 1961;43B:752–767
  32. Brittberg M, Peterson L. Introduction to an articular cartilage classification. Int Cartilage Repair Society Newsletter. 1998;1–8
  33. Brittberg M. Evaluation of cartilage injuries and cartilage repair. Osteologie. 2000;9:17–25
  34. Steadman J, Briggs K, Rodrigo J, et al. Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy. 2003;19:477–484
  35. Blevins F, Steadman J, Rodrigo J, et al. Treatment of articular cartilage defects in athletes: an analysis of functional outcome and lesion appearance. Orthopedics. 1998;21:761–767
  36. Mithoefer K, Peterson L, Mandelbaum B, et al. Articular cartilage repair in soccer players with autologous chondrocyte transplantation: functional outcome and return to competition. Am J Sports Med. 2005;33:1639–1646
  37. Mithoefer K, Minas T, Peterson L, et al. Functional outcome of knee articular cartilage repair in adolescent athletes. Am J Sports Med. 2005;33:1147–1153
  38. Peterson L. Autologous Chondrocyte Implantation. Washington, DC: American Academy of Orthopedic Surgeons; 2005;
  39. Marcacci M, Berruto M, Brocchetta D, et al. Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop. 2005;435:96–105
  40. Bachmann G, Basad E, Lommel D, et al. [MRI in the follow-up of matrix-supported autologous chondrocyte transplantation (MACI) and microfracture] [German]. Radiologe. 2004;44:773–782
  41. Behrens P, Ehlers E, Kochermann K, et al. [New therapy procedure for localized cartilage defects (Encouraging results with autologous chondrocyte implantation] [German]). MMW Fortschritte der Medizin. 1999;141:49–51
  42. Gross A, Shasha N, Aubin P. Long-term followup of the use of fresh osteochondral allografts for posttraumatic knee defects. Clin Orthop. 2005;435:79–87
  43. Knutsen G, Engebretsen L, Ludvigsen TC, et al. Autologous chondrocyte implantation compared with microfracture in the knee (A randomized trial). J Bone Joint Surg. 2004;86A:455–464
  44. Bentley G, Biant LC, Carrington RW, et al. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br. 2003;85:223–230
  45. Kish G, Hangody L. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br. 2004;86:619;author reply 619-620
  46. LaPrade RF. Autologous chondrocyte implantation was superior to mosaicplasty for repair of articular cartilage defects in the knee at one year. J Bone Joint Surg Am. 2003;85-A:2259
  47. Gudas R, Kalesinskas RJ, Kimtys V, et al. A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes. Arthroscopy. 2005;21:1066–1075
  48. Aagaard H, Verdonk R. Function of the normal meniscus and consequences of meniscal resection. Scand J Med Sci Sports. 1999;9:134–140
  49. Wojtys E, Chan D. Meniscus structure and function. Instr Course Lect. 2005;54:323–330
  50. Noyes F, Barber-Westin S. Meniscus transplantation: indications, techniques, clinical outcomes. Instr Course Lect. 2005;54:341–353
  51. Oberlander M, Shalvoy R, Hughston J. The accuracy of the clinical knee examination documented by arthroscopy (A prospective study). Am J Sports Med. 1993;21:773–778
  52. Zamber R, Teitz C, McGuire D, et al. Articular cartilage lesions of the knee. Arthroscopy. 1989;5:258–268
  53. Ogilvie-Harris D, Bauer M, Corey P. Prostaglandin inhibition and the rate of recovery after arthroscopic meniscectomy. J Bone Joint Surg [Br]. 1985;67B:567–571
  54. Evans C, Mazzocchi R, Nelson D, et al. Experimental arthritis induced by intraarticular injection of allogeneic cartilaginous particles into rabbit knees. Arthritis Rheum. 1984;27:200–207
  55. O’Connor R. The arthroscope in the management of crystal-induced synovitis of the knee. J Bone Joint Surg. 1973;55A:1443–1449
  56. Bert J, Maschka K. The arthroscopic treatment of unicompartmental gonarthrosis: a five-year follow-up study of abrasion arthroplasty plus arthroscopic debridement and arthroscopic debridement alone. Arthroscopy. 1989;5:25–32
  57. Friedman M, Berasi C, Fox J. Preliminary results with abrasion arthroplasty in the osteoarthritic knee. Clin Orthop. 1984;182:200–205
  58. Insall J. The Pridie debridement operation for osteoarthritis of the knee. Clin Orthop. 1974;101:61–67
  59. Pridie K. A method of resurfacing osteoarthritic knee joints. J Bone Joint Surg [Br]. 1959;41B:618–619
  60. Childers J, Ellwood S. Partial chondrectomy and subchondral bone drilling for chondromalacia. Clin Orthop. 1979;144:114–120
  61. Bartlett W, Skinner J, Gooding C, et al. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomized study. J Bone Joint Surg [Br]. 2005;87B:640–645
  62. Marlovits S, Singer P, Zeller P, et al. Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years. Eur J Radiol. 2006;57:16–23
  63. Slivka M, Leatherbury N, Kieswetter K, et al. Porous, resorbable, fiber-reinforced scaffolds tailored for articular cartilage repair. Tissue Eng. 2001;7:767–780
  64. Niederauer G, Slivka M, Leatherbury N, et al. Evaluation of multiphase implants for repair of focal osteochondral defects in goats. Biomaterials. 2000;21:2561–2574
  65. Marcacci M, Kon E, Zaffagnini S, et al. Multiple osteochondral arthroscopic grafting (mosaicplasty) for cartilage defects of the knee: prospective study results at 2-year follow-up. Arthroscopy. 2005;21:462–470
  66. Hangody L, Rathonyi G, Duska Z, et al. Autologous osteochondral mosaicplasty (Surgical technique). J Bone Joint Surg. 2004;86A(suppl 1):65–72
  67. Steadman J, Rodkey W, Briggs K. Microfracture to treat full-thickness chondral defects: surgical technique, rehabilitation, and outcomes. J Knee Surg. 2002;15:170–176
  68. Steadman J, Miller B, Karas S, et al. The microfracture technique in the treatment of full-thickness chondral lesions of the knee in National Football League players. J Knee Surg. 2003;16:83–86
  69. Morelli M, Nagamori J, Miniaci A. Management of chondral injuries of the knee by osteochondral autogenous transfer (mosaicplasty). J Knee Surg. 2002;15:185–190
  70. Minas T. Autologous chondrocyte implantation for focal chondral defects of the knee. Clin Orthop. 2001;391S:S349–S361
  71. Chu C, Convery F, Akeson W, et al. Articular cartilage transplantation (Clinical results in the knee). Clin Orthop. 1999;360:159–168
  72. Chen Y. Orthopedic applications of gene therapy. J Orthop Sci. 2001;6:199–207
  73. Blunk T, Sieminski A, Gooch K, et al. Differential effects of growth factors on tissue-engineered cartilage. Tissue Eng. 2002;8:73–84
  74. Frenkel S, Saadeh P, Mehrara B, et al. Transforming growth factor beta superfamily members: role in cartilage modeling. Plast Reconstr Surg. 2000;105:980–990
  75. Trippel S. Growth factors as therapeutic agents. Instr Course Lect. 1997;46:473–476
  76. Solchaga L, Dennis J, Goldberg V, et al. Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage. J Orthop Res. 1999;17:205–213
  77. Solchaga L, Yoo J, Lundberg M, et al. Hyaluronan-based polymers in the treatment of osteochondral defects. J Orthop Res. 2000;18:773–780
  78. Campoccia D, Doherty P, Radice M, et al. Semi synthetic resorbable materials from hyaluranon esterification. Biomaterials. 1998;19:2101–2127
  79. Grigolo B, Roseti L, Fiorini M, et al. Transplantation of chondrocytes seeded on a hyaluranon derivative (HYAFF 11) into cartilage defects in rabbits. Biomaterials. 2001;22:2417–2424
  80. Brun P, Abatangelo G, Radice M, et al. Chondrocyte aggregation and reorganization into three-dimensional scaffolds. J Biomed Mater Res. 1999;46:337–346
  81. Pavesio A, Abatangelo G, Borrione A, et al. Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings. In Novartis Foundation Symposium. 2003;203–217229-233

PII: S1048-6666(06)00081-4

doi: 10.1053/j.oto.2006.09.002

Operative Techniques in Orthopaedics
Volume 16, Issue 4 , Pages 218-226 , October 2006