Arthroscopic Technique for Matrix-Induced Autologous Chondrocyte Implantation for the Treatment of Large Chondral Defects in the Knee and Ankle

Matrix/membrane-induced autologous chondrocyte implantation (MACI) is a new biotechnology allowing the impregnation of autologous cultured chondrocytes onto a purified collagen membrane. The MACI implant is fixed with fibrin glue, and little or no suturing is necessary. The procedure can be performed arthroscopically or by miniarthrotomy. The use of magnetic resonance imaging shows progressive signal change with progressive loss of subchondral edema. Histologically a “hyaline-like” cartilage similar to autologous chondrocyte implantation was produced. Specialized instrumentation has been developed to allow for easy arthroscopic implantation of the MACI membrane.

Keywords: MACI, autologous chondrocytes, matrix, collagen membrane, fibrin glue, arthroscopy