Operative Techniques in Orthopaedics
Volume 16, Issue 4 , Pages 271-278 , October 2006

BST-CarGel: In Situ ChondroInduction for Cartilage Repair

  • Matthew S. Shive, PhD

      Affiliations

    • BioSyntech Canada Inc., Laval, Quebec, Canada.
    • Corresponding Author InformationAddress reprint requests to Matthew S. Shive, PhD, BioSyntech Canada Inc, 475 Armand-Frappier Boulevard, Laval, Quebec H7V 4B3, Canada.
    • ,
  • Caroline D. Hoemann, PhD

      Affiliations

    • Chemical Engineering and Institute of Biomedical Engineering, École Polytechnique, Montreal, Quebec, Canada.
    • ,
  • Alberto Restrepo, MD

      Affiliations

    • BioSyntech Canada Inc., Laval, Quebec, Canada.
    • ,
  • Mark B. Hurtig, DVM

      Affiliations

    • Comparative Orthopaedic Research Laboratory, Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
    • ,
  • Nicolas Duval, MD

      Affiliations

    • Duval Orthopedic Clinic, Laval, Quebec, Canada.
    • ,
  • Pierre Ranger, MD

      Affiliations

    • Department of Surgery, University of Montreal, Montreal, Quebec, Canada.
    • ,
  • William Stanish, MD

      Affiliations

    • Division of Orthopaedic Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.
    • ,
  • Michael D. Buschmann, PhD

      Affiliations

    • Chemical Engineering and Institute of Biomedical Engineering, École Polytechnique, Montreal, Quebec, Canada.

References 

  1. Dell’Accio F, Vanlauwe J, Bellemans J, et al. Expanded phenotypically stable chondrocytes persist in the repair tissue and contribute to cartilage matrix formation and structural integration in a goat model of autologous chondrocyte implantation. J Orthop Res. 2003;21:123–131
  2. Grande D, Pitman M, Peterson L, et al. The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantation. J Orthop Res. 1989;7:208–218
  3. Martin I, Obradovic B, Treppo S, et al. Modulation of the mechanical properties of tissue engineered cartilage. Biorheology. 2000;37:141–147
  4. Miot S, Scandiucci de Freitas P, Wirz D, et al. Cartilage tissue engineering by expanded goat articular chondrocytes. J Orthop Res. 2006;24:1078–1085
  5. Hangody L, Kish G, Karpati Z, et al. Mosaicplasty for the treatment of articular cartilage defects: application in clinical practice. Orthopedics. 1998;21:751–756
  6. Bugbee WD, Convery FR. Osteochondral allograft transplantation. Clin Sports Med. 1999;18:67–75
  7. Insall J. Intra-articular surgery for degenerative arthritis of the knee (A report of the work of the late K. H. Pridie). J Bone Joint Surg Br. 1967;49:211–228
  8. Johnson L. Arthroscopic abrasion arthroplasty historical and pathologic perspective: present status. Arthroscopy. 1986;2:54–69
  9. Steadman J, Rodkey W, Singleton S, et al. Microfracture technique for full-thickness chondral defects: technique and clinical results. Op Tech Orthop. 1997;7:300–304
  10. Jakobsen RB, Engebretsen L, Slauterbeck JR. An analysis of the quality of cartilage repair studies. J Bone Joint Surg Am. 2005;87:2232–2239
  11. Smith GD, Knutsen G, Richardson JB. A clinical review of cartilage repair techniques. J Bone Joint Surg Br. 2005;87:445–449
  12. Hurtig MB, Fretz PB, Doige CE, et al. Effects of lesion size and location on equine articular cartilage repair. Can J Vet Res. 1988;52:137–146
  13. Chevrier A, Hoemann C, Sun J, et al. Chitosan-glycerol phosphate/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects. Osteoarthritis Cartilage. 2006;Sep 25 [Epub ahead of print]
  14. Chevrier A, Sun J, Hoemann C, et al. Early Reparative Events in Adult Rabbits With Drilled Chondral Defects Treated With an Injectable Chitosan-Glycerol Phosphate Implant. Gent, Belgium: International Cartilage Repair Society; 2004;
  15. Meachim G, Roberts C. Repair of the joint surface from subarticular tissue in the rabbit knee. J Anat. 1971;109:317–327
  16. Mitchell N, Shepard N. The resurfacing of adult rabbit articular cartilage by multiple perforations through the subchondral bone. J Bone Joint Surg Am. 1976;58:230–233
  17. Shapiro F, Koide S, Glimcher MJ. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg Am. 1993;75:532–553
  18. Morgenstern E, Ruf A, Patscheke H. Ultrastructure of the interaction between human platelets and polymerizing fibrin within the first minutes of clot formation. Blood Coagul Fibrinolysis. 1990;1:543–546
  19. Breinan HA, Minas T, Hsu HP, et al. Effect of cultured autologous chondrocytes on repair of chondral defects in a canine model. J Bone Joint Surg Am. 1997;79:1439–1451
  20. Hoemann CD, Hurtig M, Rossomacha E, et al. Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects. J Bone Joint Surg Am. 2005;87:2671–2686
  21. Johnson LL. Characteristics of immediate postarthroscopic blood clot formation in the knee joint. Arthroscopy. 1991;7:14–23
  22. Kumar M, Muzzarelli R, Muzzarelli C, et al. Chitosan chemistry and pharmaceutical perspectives. Chem Rev. 2004;104:6017–6084
  23. Mattioli-Belmonte M, Muzzarelli B, Muzzarelli R. Chitin and chitosan in wound healing and other biomedical applications. Carbohydrates Eur. 1997;19:30–36
  24. Shigemasa Y, Minami S. Applications of chitin and chitosan for biomaterials. Biotechnol Genet Eng Rev. 1995;13:383–420
  25. Chenite A, Chaput C, Wang D, et al. Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials. 2000;21:2155–2161
  26. Hoemann C, Sun J, McKee M, et al. In: Rabbit Hyaline Cartilage Repair After Marrow Stimulation Depends on the Surgical Approach and a Chitosan-GP Stabilised In-Situ Blood Clot. Chicago, IL: Orthopaedic Research Society; 2005;p. 1372
  27. Hoemann C, Sun J, McKee M, et al. Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects. Osteoarthritis Cartilage. 2006;Aug 6 [Epub ahead of print]
  28. Dorotka R, Bindreiter U, Macfelda K, et al. Marrow stimulation and chondrocyte transplantation using a collagen matrix for cartilage repair. Osteoarthritis Cartilage. 2005;13:655–664
  29. Vasara A, Hyttinen M, Lammi M, et al. Subchondral bone reaction associated with chondral defect and attempted cartilage repair in goats. Calcif Tissue Int. 2004;74:107–114
  30. Vachon A, Bramlage L, Gabel A, et al. Evaluation of the repair process of cartilage defects of the equine third carpal bone with and without subchondral bone perforation. Am J Vet Res. 1986;47:2637–2645
  31. Frisbie D, Oxford J, Southwood L, et al. Early events in cartilage repair after subchondral bone microfracture. Clin Orthop. 2003;215–227
  32. Frisbie D, Trotter G, Powers B, et al. Arthroscopic subchondral bone plate microfracture technique augments healing of large chondral defects in the radial carpal bone and medial femoral condyle of horses. Vet Surg. 1999;28:242–255
  33. Hanie E, Sullins K, Powers B, et al. Healing of full-thickness cartilage compared with full-thickness cartilage and subchondral bone defects in the equine third carpal bone. Equine Vet J. 1992;24:382–386
  34. Jackson D, Lalor P, Aberman H, et al. Spontaneous repair of full-thickness defects of articular cartilage in a goat model (A preliminary study). J Bone Joint Surg Am. 2001;83-A:53–64
  35. Howard R, McIlwraith C, Trotter G, et al. Long-term fate and effects of exercise on sternal cartilage autografts used for repair of large osteochondral defects in horses. Am J Vet Res. 1994;55:1158–1167
  36. Johnson L. Arthroscopic abrasion arthroplasty: a review. Clin Orthop. 2001;S306–S317
  37. Buschmann MD, Hoemann CD, Hurtig MB, et al. Cartilage repair with chitosan/glycerol-phosphate stabilised blood clots. In:  Williams RJ editors. Cartilage Repair: Analysis and Strategies. Humana Press: Totowa, NJ; 2006;p. 83–106
  38. Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15:1833–1840

 The authors acknowledge funding sources for animal studies, which include BioSyntech Canada Inc, Canadian Institutes of Health Research (CIHR), Canadian Arthritis Networks of Centres of Excellence (CAN), and Canada Research Chairs (CRC).

PII: S1048-6666(06)00072-3

doi: 10.1053/j.oto.2006.08.001

Operative Techniques in Orthopaedics
Volume 16, Issue 4 , Pages 271-278 , October 2006

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